Atherosclerosis endothelial activation quantification in vivo with fluorine magnetic resonance imaging and spectroscopy
نویسندگان
چکیده
Background Endothelial activation is one of the necessary initial steps in the formation of atherosclerotic plaque that facilitates immune cell recruitment and retention. To image and quantify early markers of endothelial inflammation, we recently developed a multiplexing peptide-based targeting system for post-formulation functionalization of perfluorocarbon (19F) nanoparticles (PFC NP) that is intrinsically quantifiable at a binding site based on magnetic resonance spectroscopy. The approach is now demonstrated in vivo to detect and quantify VCAM-1 in ApoE-/mouse aorta.
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